What antibodies are typically elevated in serum for a patient with post streptococcal glomerulonephritis?

What antibodies are typically elevated in serum for a patient with post streptococcal glomerulonephritis?

• A. Anti-dsDNA
• B. ASO + Anti-DNAse B
• C. Anti-neutrophil cytoplasmic antibodies
• D. Anti-streptolysin O

Answer: (B)

In post-streptococcal glomerulonephritis, the typical antibodies elevated in serum are anti-streptolysin O (ASO) and anti-DNAse B. These antibodies indicate a recent infection with Streptococcus pyogenes, which is often responsible for causing this condition following a throat or skin infection. ASO is produced in response to streptolysin O, which is a toxin produced by Streptococcus. The presence of elevated ASO levels signals an immune response to streptococcal infection. Similarly, anti-DNAse B antibodies are generated in response to the streptococcal enzyme DNAse B. The elevation of both ASO and anti-DNAse B is characteristic of the post-infectious glomerulonephritis that follows a streptococcal infection. This increase in antibody levels is part of the humoral immune response to the streptococcal antigen, which plays a crucial role in the subsequent immune-mediated injury to the kidneys seen in post-streptococcal glomerulonephritis. The other antibodies listed in the alternatives are associated with different conditions and are not relevant in the context of post-streptococcal

In post-streptococcal glomerulonephritis, the typical antibodies elevated in serum are anti-streptolysin O (ASO) and anti-DNAse B. These antibodies indicate a recent infection with Streptococcus pyogenes, which is often responsible for causing this condition following a throat or skin infection.

ASO is produced in response to streptolysin O, which is a toxin produced by Streptococcus. The presence of elevated ASO levels signals an immune response to streptococcal infection. Similarly, anti-DNAse B antibodies are generated in response to the streptococcal enzyme DNAse B. The elevation of both ASO and anti-DNAse B is characteristic of the post-infectious glomerulonephritis that follows a streptococcal infection.

This increase in antibody levels is part of the humoral immune response to the streptococcal antigen, which plays a crucial role in the subsequent immune-mediated injury to the kidneys seen in post-streptococcal glomerulonephritis. The other antibodies listed in the alternatives are associated with different conditions and are not relevant in the context of post-streptococcal